In the seventeenth century the microscope opened up a new world of observation, and, according to Catherine Wilson, profoundly revised the thinking of scientists and philosophers alike. The interior of nature, once closed off to both sympathetic intuition and direct perception, was now accessible with the help of optical instruments. The microscope led to a conception of science as an objective, procedure-driven mode of inquiry and renewed interest in atomism and mechanism. Focusing on the earliest forays into microscopical research, (...) from 1620 to 1720, this book provides us with both a compelling technological history and a lively assessment of the new knowledge that helped launch philosophy into the modern era. Wilson argues that the discovery of the microworld--and the apparent role of living animalcula in generation, contagion, and disease--presented metaphysicians with the task of reconciling the ubiquity of life with human-centered theological systems. It was also a source of problems for philosophers concerned with essences, qualities, and the limits of human knowledge, whose positions are echoed in current debates about realism and instrument-mediated knowledge. Covering the contributions of pioneering microscopists (Leeuwenhoek, Swammerdam, Malpighi, Grew, and Hooke) and the work of philosophers interested in the microworld (Bacon, Descartes, Leibniz, Malebranche, Locke, and Berkeley), she challenges historians who view the abstract sciences as the sole catalyst of the Scientific Revolution as she stresses the importance of observational and experimental science to the modern intellect. (shrink)

This edited volume of 13 new essays aims to turn past discussions of natural kinds on their head. Instead of presenting a metaphysical view of kinds based largely on an unempirical vantage point, it pursues questions of kindedness which take the use of kinds and activities of kinding in practice as significant in the articulation of them as kinds. The book brings philosophical study of current and historical episodes and case studies from various scientific disciplines to bear on natural kinds (...) as traditionally conceived of within metaphysics. Focusing on these practices reveals the different knowledge-producing activities of kinding and processes involved in natural kind use, generation, and discovery. -/- Specialists in their field, the esteemed group of contributors use diverse empirically responsive approaches to explore the nature of kindhood. This groundbreaking volume presents detailed case studies that exemplify kinding in use. Newly written for this volume, each chapter engages with the activities of kinding across a variety of disciplines. Chapter topics include the nature of kinds, kindhood, kinding, and kind-making in linguistics, chemical classification, neuroscience, gene and protein classification, colour theory in applied mathematics, homology in comparative biology, sex and gender identity theory, memory research, race, extended cognition, symbolic algebra, cartography, and geographic information science. -/- The volume seeks to open up an as-yet unexplored area within the emerging field of philosophy of science in practice, and constitutes a valuable addition to the disciplines of philosophy and history of science, technology, engineering, and mathematics. -/- Contributions from a diverse group of established and junior scholars in the fields of Philosophy and History and Philosophy of Science including Hasok Chang, Jordi Cat, Sally Haslanger, Joyce C. Havstad, Catherine Kendig, Bernhard Nickel, Josipa Petrunic, Samuli Pöyhönen, Thomas A. C. Reydon, Quayshawn Spencer, Jackie Sullivan, Michael Wheeler, and Rasmus Grønfeldt Winther. (shrink)

After defining plasticity in terms of its active embodiments, Malabou applies the notion to the work of Hegel, Heidegger, Levinas, Levi-Strauss, Freud, and ...

_After Writing_ provides a significant contribution to the growing genre of works which offers a challenge to modern and postmodern accounts of Christianity.

The experience of the impossible churns up in our epoch whenever a collective dream turns to trauma: politically, sexually, economically, and with a certain ultimacy, ecologically. Out of an ancient theological lineage, the figure of the cloud comes to convey possibility in the face of the impossible. An old mystical nonknowing of God now hosts a current knowledge of uncertainty, of indeterminate and interdependent outcomes, possibly catastrophic. Yet the connectivity and collectivity of social movements, of the fragile, unlikely webs of (...) an alternative notion of existence, keep materializing--a haunting hope, densely entangled, suggesting a more convivial, relational world. Catherine Keller brings process, feminist, and ecopolitical theologies into transdisciplinary conversation with continental philosophy, the quantum entanglements of a "participatory universe," and the writings of Nicholas of Cusa, Walt Whitman, A. N. Whitehead, Gilles Deleuze, and Judith Butler, to develop a "theopoetics of nonseparable difference." Global movements, personal embroilments, religious diversity, the inextricable relations of humans and nonhumans--these phenomena, in their unsettling togetherness, are exceeding our capacity to know and manage. By staging a series of encounters between the nonseparable and the nonknowable, Keller shows what can be born from our cloudiest entanglement. (shrink)

In the last decade, the organization of pharmaceutical research on neglected tropical diseases has undergone transformative change. In a context of perceived “market failure,” the development of new medicines is increasingly handled by public-private partnerships. This shift toward hybrid organizational models depends on a particular form of exchange: the sharing of proprietary assets in general and of intellectual property rights in particular. This article explores the paradoxical role of private property in this new configuration of global health research and development. (...) Rather than a tool to block potential competitors, proprietary assets function as a lever to attract others into risky collaborative ventures; instead of demarcating public and private domains, the sharing of property rights is used to increase the porosity of that boundary. This reimagination of the value of property is connected to the peculiar timescape of global health drug development, a promissory orientation to the future that takes its clearest form in the centrality of “virtual” business models and the proliferation of strategies of deferral. Drawing on the anthropological literature on inalienable possessions, we reconsider property’s traditional exclusionary role and discuss the possibility that the new pharmaceutical “commons” proclaimed by contemporary global health partnerships might be the precursor of future enclosures. (shrink)

This unique book challenges the traditional distinction between eros, the love found in Greek thought, and agape, the love characteristic of Christianity. Focusing on a number of classic texts, including Plato's Symposium and Lysis, Aristotle's Ethics and Metaphysics,, and famous passages in Gregory of Nyssa, Origen, Dionysius the Areopagite, Plotinus, Augustine, and Thomas Aquinas, the author shows that Plato's account of eros is not founded on self-interest. In this way, she restores the place of erotic love as a Christian motif, (...) and unravels some longstanding confusions in philosophical discussions of love. (shrink)

Epicureanism is commonly associated with a carefree view of life and the pursuit of pleasures, particularly the pleasures of the table. However it was a complex and distinctive system of philosophy that emphasized simplicity and moderation, and considered nature to consist of atoms and the void. Epicureanism is a school of thought whose legacy continues to reverberate today.In this Very Short Introduction, Catherine Wilson explains the key ideas of the School, comparing them with those of the rival Stoics and (...) with Kantian ethics, and tracing their influence on the development of scientific and political thought from Locke, Newton, and Galileo to Rousseau, Marx, Bentham, and Mill. She discusses the adoption and adaptation of Epicurean motifs in science, morality, and politics from the 17th Century onwards and contextualises the significance of Epicureanism in modern life. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable. (shrink)

The book is about three things. First, how Ancient thinkers perceived humans as like or unlike other animals; second about the justification for taking a humane attitude towards natural things; and third about how moral claims count as true, and how they can be discovered or acquired. Was Aristotle was right to see continuity in the psychological functions of animal and human souls? The question cannot be settled without taking a moral stance. As we can either focus on continuity or (...) on discontinuities, how should natural science draw the boundaries? Moral agents act and react in a world that they see under a certain description, and there is no value free science that can settle what is the correct description. This book asks us to think about where moral justification could come from, and suggests that the supposed ‘moral status’ of the object cannot provide the answer. For the moral status of the object is a product of our own imagination, and once we see that, we also see that there remains the question where we ought to have the will to see it. Furthermore, since the perception of moral truth involves the development of imagination and will, the means to attain it will be better served by engagement with poetry and literature than with enquiries that seek to exclude the engagement of the imagination, or any appeal to the beauty of nature or the love of one's fellow creatures. (shrink)

Philosophical investigation in synthetic biology has focused on the knowledge-seeking questions pursued, the kind of engineering techniques used, and on the ethical impact of the products produced. However, little work has been done to investigate the processes by which these epistemological, metaphysical, and ethical forms of inquiry arise in the course of synthetic biology research. An attempt at this work relying on a particular area of synthetic biology will be the aim of this chapter. I focus on the reengineering of (...) metabolic pathways through the manipulation and construction of small DNA-based devices and systems synthetic biology. Rather than focusing on the engineered products or ethical principles that result, I will investigate the processes by which these arise. As such, the attention will be directed to the activities of practitioners, their manipulation of tools, and the use they make of techniques to construct new metabolic devices. Using a science-in-practice approach, I investigate problems at the intersection of science, philosophy of science, and sociology of science. I consider how practitioners within this area of synthetic biology reconfigure biological understanding and ethical categories through active modelling and manipulation of known functional parts, biological pathways for use in the design of microbial machines to solve problems in medicine, technology, and the environment. We might describe this kind of problem-solving as relying on what Helen Longino referred to as “social cognition” or the type of scientific work done within what Hasok Chang calls “systems of practice”. My aim in this chapter will be to investigate the relationship that holds between systems of practice within metabolic engineering research and social cognition. I will attempt to show how knowledge and normative valuation are generated from this particular network of practitioners. In doing so, I suggest that the social nature of scientific inquiry is ineliminable to both knowledge acquisition and ethical evaluations. (shrink)

Poststructuralism changes the way we understand the relations between human beings, their culture, and the world. Following a brief account of the historical relationship between structuralism and poststructuralism, this Very Short Introduction traces the key arguments that have led poststructuralists to challenge traditional theories of language and culture. Whilst the author discusses such well-known figures as Barthes, Foucault, Derrida, and Lacan, she also draws pertinent examples from literature, art, film, and popular culture, unfolding the poststructuralist account of what it means (...) to be a human being. (shrink)

This volume argues that feminist theory can provide distinctive and potent resources to confront and take on post-truth. By ‘post-truth’, we refer to a variety of discourses and practices that subvert the sense that we share a common world. Because post-truth undermines the norms and conditions that make possible shared political practices and institutions, post-truth politics is fundamentally anti-democratic. The most common response to post-truth has, however, come from those who call for reinstating truth and rationality, with special emphasis on (...) returning to the facts and fact-checking. From a feminist perspective, this approach is worrisome as it risks idealizing the connection between democracy and truth, disowning the tensions within and between them, and suppressing contestation tout court. Diagnosing the post-truth moment we face two challenges: on the one hand, there is too much contestation (of the post-truth variety); on the other hand, there is too much depoliticization (of the technocratic or rationalist variety). This binary effectively limits the space within which critiques of post-truth can meaningfully intervene. Feminist takes on post-truth must take seriously this dual challenge at the crossroads of depoliticization and hyper-politicization, acknowledging the anti-democratic dangers of post-truth while keeping open the possibility and necessity of contestation. Our gambit is that effective rejoinders to post-truth can be found in practices that affirm rather than repudiate a plural world. Rather than simply condemning or dismissing post-truth as mad or irrational, the feminist theorists in this volume move closer to what we’re up against in order to see how encounters with reality provide opportunities to radicalize and politicize our relation to it in ways that do not undermine the conditions for others to do the same. This volume is an attempt to open new, and emphasize existing, feminist modes of response that might break the deadlock in the post-truth discourse. (shrink)

A study of Hippolytus of Rome and his treatment of Presocratic Philosophy, used as a case study to argue against the use of collections of fragments and in favour of the idea of reading "embedded texts" with attention to the interpretation and interests of the quoting author. A study of methodology in early Greek Philosophy. Includes novel interpretations of Heraclitus and Empedocles, and an argument for the unity of Empedocles's poem.

Quelle est l'intention de Platon lorsqu'il fait de Socrate un virtuose de l'étymologie dans le Cratyle? Préciser les rapports entre la " science des lettres " qui se constitue en son siècle et la nouvelle théorie des Idées qu'il élabore. Socrate s'entretient avec le jeune Hermogène puis avec l'énigmatique Cratyle des rapports entre les mots et les choses. La rectitude des noms est-elle affaire de convention, ainsi que le soutient Hermogène? Ou s'agit-il d'un accord " naturel ", comme le prétend (...) Cratyle? Découvre-t-on cet accord par science ou par inspiration? Au terme du débat, après avoir mis à l'épreuve toutes les ressources de la " science des lettres ", Socrate propose une nouvelle théorie du nom, instrument faillible construit pour faire voir la réalité en la minant. Il dessine aussi un ordre des priorités : il faut d'abord connaître les êtres, puis les noms. " Savoir comment il faut apprendre ou découvrir les êtres, peut-être est-ce là trop lourde tâche pour toi et moi! C'est déjà beau de reconnaître qu'il ne faut pas partir des noms. ". (shrink)

In this introduction to a classic philosophical text, Catherine Wilson examines the arguments of Descartes' famous Meditations, the book which launched modern philosophy. Drawing on the reinterpretations of Descartes' thought of the past twenty-five years, she shows how Descartes constructs a theory of the mind, the body, nature, and God from a premise of radical uncertainty. She discusses in detail the historical context of Descartes' writings and their relationship to early modern science, and at the same time she introduces (...) concepts and problems that define the philosophical enterprise as it is understood today. Following closely the text of the Meditations and meant to be read alongside them, this survey is accessible to readers with no previous background in philosophy. It is well-suited to university-level courses on Descartes, but can also be read with profit by students in other disciplines. (shrink)

In the United States, the decision of whether to withdraw or continue to provide artificial nutrition and hydration (ANH) for patients in a permanent vegetative state (PVS) is placed largely in the hands of surrogate decision-makers, such as spouses and immediate family members. This practice would seem to be consistent with a strong national emphasis on autonomy and patient-centered healthcare. When there is ambiguity as to the patient's advanced wishes, the presumption has been that decisions should weigh in favor of (...) maintaining life, and therefore, that it is the withdrawal rather than the continuation of ANH that requires particular justification. I will argue that this default position should be reversed. Instead, I will argue that the burden of justification lies with those who would continue artificial nutrition and hydration (ANH), and in the absence of knowledge as to the patient's advanced wishes, it is better to discontinue ANH. In particular, I will argue that among patients in PVS, there is not a compelling interest in being kept alive; that in general, we commit a worse violation of autonomy by continuing ANH when the patient's wishes are unknown; and that more likely than not, the maintenance of ANH as a bridge to a theoretical future time of recovery goes against the best interests of the patient. (shrink)

This article explores a problem of the articulation of an adequate account of the human person in both philosophical and nursing theory. It follows the lead of philosopher Norris Clarke in suggesting that there has been a significant division in the way philosophers have looked at the human person and goes on to suggest that this division is paralleled in prominent nursing theories. The paper reviews and argues for the synthesis of two contemporary philosophic theories of the person that arise (...) from the traditional philosophical division, and uses Clarke's account to show the ontological need for such a synthesis if we are to have a more adequate account of the human person. Next, accounts of the person identified in a number of the prominent theories of nursing are briefly reviewed revealing the vast complexity of the person encountered in nursing practice. It is suggested that each new theory of nursing is founded, at least in part, on the need to account for attributes of the person missing from prior nursing theories. It will be seen that the synthesized account of the person argued for here more adequately accounts for the various attributes identified in these nursing accounts and it is hoped that this synthesized account will serve as a somewhat more complete basis for a continued exploration of the persons encountered in nursing practice in its many and varied manifestations. (shrink)

The practice of terminating a pregnancy following the diagnosis of a fetal abnormality raises questions about notions of bodily normality and the ways these shape ethical decision-making. This is particularly the case with terminations done on the basis of ostensibly minor morphological anomalies, such as cleft lip and isolated malformations of the limbs or digits. In this paper, I examine a recent case of selective termination after a morphology ultrasound scan revealed the fetus to be missing a hand . Using (...) the work of Georges Canguilhem, I show that a person with acheiria could be considered normal. Further, I show that this case reveals a kind of “undecidability” in the significance of fetal sex/gender and disability in termination. From this, I consider the conceptual interaction of disability with sex/gender, to argue that the ethics of disability termination are not as distinct from those of sex/gender selection as is commonly supposed. (shrink)

Moral properties are widely held to be response‐dependent properties of actions, situations, events and persons. There is controversy as to whether the putative response‐dependence of these properties nullifies any truth‐claims for moral judgements, or rather supports them. The present paper argues that moral judgements are more profitably compared with theoretical judgements in the natural sciences than with the judgements of immediate sense‐perception. The notion of moral truth is dependent on the notion of moral knowledge, which in turn is best understood (...) as a possible endpoint of theory change for the better. (shrink)

This article first examines pervasive present‐day attitudes toward humility before turning to Thomas Aquinas and Zhu Xi for their more positive treatments of this disposition. It then considers their ideas about how humility is related to our human limitations, before surveying how they think it should be expressed in our relationships with our neighbours. The article looks at what Thomas and Zhu have to say about excessive pride in rulers before closing in the Conclusion with some thoughts about the viability (...) of humility as a virtue for the strong, and its especial importance in contemporary politics. (shrink)

Introduction We search for origins the way some cats chase their tails. After brief bursts of frenetic spinning, we think we have a grasp of our topic, ...

Augustine’s _Confessions_ is one of the most significant works of Western culture. Cast as a long, impassioned conversation with God, it is intertwined with passages of life-narrative and with key theological and philosophical insights. It is enduringly popular, and justly so. The Routledge Guidebook to Augustine’s Confessions is an engaging introduction to this spiritually creative and intellectually original work. This guidebook is organized by themes: the importance of language creation and the sensible world memory, time and the self the afterlife (...) of the Confessions. Written for readers approaching the _Confessions_ for the first time, this guidebook addresses the literary, philosophical, historical and theological complexities of the work in a clear and accessible way. Excerpts in both Latin and English from this seminal work are included throughout the book to provide a close examination of both the autobiographical and theoretical content within the _Confessions. _. (shrink)

One of the main contributions of A Feminist Theory of Refusal is its connection of everyday action and prefigurative practices with an explicit commitment to structural change. But how such change happens, and what kind of relations it implies between ‘the city’ (as the existing political community) and feminist heterotopias of refusal, remains unclear. Reading Honig’s work as a prefigurative theory, I argue that it links moments of doing-otherwise with moments of institutional politics, sparking questions about the conditions of a (...) successful return to the city. I then develop these conditions through a case study of the feminist activism of Women on Waves; and argue that feminist refusal can lead to political transformation if it durably connects practices inside and outside the city. (shrink)

A leading philosopher shows that if the pursuit of happiness is the question, Epicureanism is the answer Epicureanism has a reputation problem, bringing to mind gluttons with gout or an admonition to eat, drink, and be merry. In How to Be an Epicurean, philosopher Catherine Wilson shows that Epicureanism isn't an excuse for having a good time: it's a means to live a good life. Although modern conveniences and scientific progress have significantly improved our quality of life, many of (...) the problems faced by ancient Greeks -- love, money, family, politics -- remain with us in new forms. To overcome these obstacles, the Epicureans adopted a philosophy that promoted reason, respect for the natural world, and reverence for our fellow humans. By applying this ancient wisdom to a range of modern problems, from self-care routines and romantic entanglements to issues of public policy and social justice, Wilson shows us how we can all fill our lives with purpose and pleasure. (shrink)

Metaethics from a First Person Standpoint addresses in a novel format the major topics and themes of contemporary metaethics, the study of the analysis of moral thought and judgement. Metathetics is less concerned with what practices are right or wrong than with what we mean by 'right' and 'wrong.' Looking at a wide spectrum of topics including moral language, realism and anti-realism, reasons and motives, relativism, and moral progress, this book engages students and general readers in order to enhance their (...) understanding of morality and moral discourse as cultural practices. Catherine Wilson innovatively employs a first-person narrator to report step-by-step an individual's reflections, beginning from a position of radical scepticism, on the possibility of objective moral knowledge. The reader is invited to follow along with this reasoning, and to challenge or agree with each major point. Incrementally, the narrator is led to certain definite conclusions about 'oughts' and norms in connection with self-interest, prudence, social norms, and finally morality. Scepticism is overcome, and the narrator arrives at a good understanding of how moral knowledge and moral progress are possible, though frequently long in coming. Accessibly written, Metaethics from a First Person Standpoint presupposes no prior training in philosophy and is a must-read for philosophers, students and general readers interested in gaining a better understanding of morality as a personal philosophical quest."--Publisher's website. (shrink)

This paper discusses the significance for the philosophy of perception and aesthetics of certain productions of the ‘offline brain’. These are experienced in hypnagogic and other trance states, and in disease- or drug-induced hallucination. They bear a similarity to other visual patterns in nature, and reappear in human artistry, especially of the craft type. The reasons behind these resonances are explored, along with the question why we are disposed to find geometrical complexity and ‘supercolouration’ beautiful. The paper concludes with a (...) plea on behalf of neuroaesthetics, but with a caution or two. (shrink)

In this essay, I argu e that Descartes considered his theory that the body is an inn ervated machine – in which the soul is situated – to be his most original contribution to philosophy. His ambition to prove the immortality of the soul was very poorly realized, a predictable outcome, insofar as his aims were ethical, not theological. His dualism accordingly requires reassessment.

This article examines the claim that there are two different and often incompatible ‘worlds’ within which contractual relationships can be placed—a real world created by the parties and an artificial world created by contract law and formal contract documents. This distinction, often made by sociolegal scholars, is usually accompanied by the suggestion that legal reasoning might be improved by more attention to the real world of contracting at the expense of the artificial world of documents and classical doctrine. After examining (...) the relationship between trust and contract, the role of legal institutions in supporting agreement-making and the reasons parties might have for formalizing commercial relationships, the article argues that a sharp distinction between the real and paper deal cannot be drawn and that in many commercial agreements these must be understood as integrated phenomena, rather than wholly discrete aspects of contracting behaviour. The article then considers the capacity of contract law to respond to this finding, with particular reference to the law's approach to uncertainty in agreements and the contextual approach to contract interpretation as developed by Lord Hoffmann in Investors Compensation Scheme and subsequent cases. (shrink)

Alliant l’étude de sources historiques et les méthodes anthropologiques d’analyse de terrains et d’entretiens, Lucy Green étudie le rapport à la musique des femmes sous l’angle de l’éducation féminine, entendue comme éducation à la féminité, renforcée ou menacée par la pratique musicale. Dans la première partie de l’ouvrage, l’auteur se penche sur la signification culturelle et sociale des pratiques musicales féminines à travers l’histoire. S’interrogeant sur la tendance de ces dernières à tr...

L’ouvrage de Marie Buscatto constitue une riche contribution à l’étude des rapports sociaux de sexe à l’intérieur du monde du travail et de l’art. Au travers d’une étude ethnographique de près de dix ans dans le milieu du jazz français, par des entretiens, des questionnaires et l’analyse de la presse spécialisée, l’auteur met en lumière la double ségrégation dont les artistes féminines (seulement 8% de la « population jazz ») font l’objet au sein de ce microcosme. Ségrégation de type horizont...

In lieu of an abstract, here is a brief excerpt of the content:Many scholars have contended that Clare of Assisi’s original intention upon leaving her family home to take up religious life sometime around 1211 was to lead a life essentially like that of the mendicant friars.1 She and the women who soon joined her would be not only poor and penitential, but also itinerant and apostolic. Like the friars their life would be marked by both insertion into the world (...) and seclusion from it as they alternated between active service and recollected contemplation. The important proof text for this claim is a passage in a letter composed by Jacques de Vitry in 1216, just five years after Clare’s conversion. Many scholars, including Paul Sabatier, Luigi Pellegrini, Roberto Rusconi, Marco Bartoli, Ingrid Peterson, Chiara Frugoni, Giovanni Boccali, and Chiara Augusta Lainati believe the text to be the earliest witness to the manner of life led by Clare and her followers during their initial years.2 The letter has been used to argue further that the women were explicitly grouped together with the Lesser Brothers, were known by the parallel title of “Lesser Sisters,” and had the freedom to come and go as they wished during their early years in San Damiano.Since claims about the women’s early likeness to the friars’ mendicant way of life are often made as brief assertions resting on Jacques’s letter, I think it important to consider in a more detained fashion the provocative passage thought to support them. Closer scrutiny of Jacques’s text shows that while none of these claims can be entirely ruled out, importantly, none can be supported with any solid evidence. I agree essentially with scholars such as Lilly Zarncke, Ernest McDonnell, Maria Pia Alberzoni, Jacques Dalarun, and Lezlie Knox who consider the letter’s language too general to know if it refers specifically to Clare and her sisters.3 I suggest, furthermore, that there are reasons to conclude that this is certainly unlikely if the passage is interpreted to mean, specifically, that Clare and her sisters carried on an active apostolate outside of San Damiano.Jacques de Vitry is generally recognized as one of the most astute and forward-thinking observers of his time in terms of recognizing the importance of new religious groups. A Parisian master, canon regular, and bishop, Jacques had the opportunity to live in a variety of settings, including his native France, the Low Countries, Italy, and the holy land.4 In 1216, he traveled from Liège in the Low Countries to Perugia to be consecrated bishop by Honorius III, who himself had just been elevated to the papacy.5 Along with observations about other matters, Jacques shared the following comment about religious men and women in a letter that he sent almost certainly to a group of his friends back in Liège. He was writing in the early days of October 1216 as he was leaving Italy on a boat that would carry him to his new episcopal see in Acre. The letter, the first of six that survive, is prized not only for its reference to the Lesser Sisters, but also as the very first written testimony regarding the Franciscan movement in general. The great nineteenth-century historian Paul Sabatier thought it provided a more vivid and precise description of Francis’s ministry than any single passage contained in his early biographies.6 The passage, which represents less than seven percent of the entire letter, is rendered thus in a widely available English translation:I found one consolation in those parts, nevertheless: many men and women [multi enim utriusque sexus], rich and worldly, after renouncing everything for Christ, fled the world. They are called Lesser Brothers and Lesser Sisters [fratres minores et sorores minores]. They are held in great esteem by the Lord Pope and the cardinals. They do not occupy themselves with temporal affairs, but work each day with great desire and.. (shrink)

For almost 30 years the ion channel that initiates the ON visual pathway in vertebrate vision has remained elusive. Recent findings now indicate that the pathway, which begins with unbinding of glutamate from the metabotropic glutamate receptor 6 (mGluR6), ends with the opening of the transient receptor potential (TRP)M1 cation channel. As a component of the mGluR6 signal transduction pathway, mutations in TRPM1 would be expected to cause congenital stationary night blindness (CSNB), and several such mutations have already been identified (...) in CSNB families. Furthermore, expression of TRPM1 in both the retina and skin raises the possibility that a genetic link exists between certain types of visual and skin disorders. (shrink)